Description

Pim1-In-1 is a potent and selective small-molecule inhibitor of the Pim-1 kinase, a key regulator of cell survival and proliferation. This high-purity research chemical is essential for advancing studies in oncology, hematology, and signal transduction pathways. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies for target validation, mechanism-of-action studies, and preclinical drug development.

Application

• Oncology Research: Investigation of Pim-1 kinase's role in tumor growth, survival, and resistance mechanisms in various cancers.
• Biochemical Assay Development: Serving as a reference standard and positive control in high-throughput screening (HTS) and enzymatic assays.
• Signal Transduction Studies: Elucidating the downstream effects of Pim-1 inhibition on critical cellular pathways like PI3K/Akt/mTOR and JAK/STAT.
• Hematological Research: Exploring therapeutic potential in hematologic malignancies where Pim-1 is often overexpressed.
• Preclinical Drug Discovery: Used as a lead compound or tool molecule for structure-activity relationship (SAR) studies and analog synthesis.
• Cell Biology: Studying the impact of Pim-1 inhibition on cell cycle progression, apoptosis, and autophagy in vitro.

Basic Information

Product Name	Pim1-In-1
CAS No.	1417630-95-5
Molecular Formula	C₂₀H₂₀N₆O₂
Molecular Weight	376.42 g/mol
Synonyms	PIM1-IN-1; 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 6-[(3R,5S)-3,5-dimethyl-1-piperazinyl]-3-(1-methyl-1H-pyrazol-4-yl)-; (R,S)-6-(3,5-Dimethylpiperazin-1-yl)-3-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; Pim-1 Kinase Inhibitor I; Pim1 Inhibitor; PIM1 Kinase Inhibitor
EINECS	Contact for details

Quality Control

Our Pim1-In-1 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade standards. Custom synthesis and purification to meet specific project requirements are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.