Description

3-Bromo-4-Fluoropyridin-2-Amine is a high-purity, multi-functional halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. This compound matters for its role in constructing complex molecular architectures, particularly in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries seeking to introduce specific halogenated motifs into their target molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of drug candidates, especially kinase inhibitors and other small molecule therapeutics.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the fluorine and bromine substituents for bioactivity and metabolic stability.
• Material Science Precursor: Employed in the creation of specialized ligands for catalysis and as a monomer for functionalized polymers.
• Chemical Biology Probe: Serves as a versatile handle for bioconjugation and the development of molecular probes due to its reactive amine and halogen groups.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig).
• Library Synthesis: A valuable building block for generating diverse compound libraries in medicinal chemistry for high-throughput screening.

Basic Information

Product Name	3-Bromo-4-Fluoropyridin-2-Amine
CAS No.	1417407-29-4
Molecular Formula	C5H4BrFN2
Molecular Weight	191.00 g/mol
Synonyms	2-Amino-3-bromo-4-fluoropyridine; 4-Fluoro-3-bromopyridin-2-amine; 3-Bromo-4-fluoro-2-pyridinamine; 3-Bromo-4-fluoropyridine-2-amine; 2-Pyridinamine, 3-bromo-4-fluoro-; 1417407-29-4
EINECS	Contact for details

Quality Control

Our 3-Bromo-4-Fluoropyridin-2-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor quality protocols to meet specific customer requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.