Description

4-(Bromomethyl)-3-Fluorobenzaldehyde is a versatile and high-value aromatic aldehyde building block containing both bromomethyl and fluorine substituents. This bifunctional compound is essential for advanced organic synthesis, enabling the introduction of both electrophilic and fluorinated aromatic moieties in a single step. It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the fluorine atom enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Functional Material Precursor: Employed in the synthesis of organic electronic materials, liquid crystals, and advanced polymers where fluorinated aromatic units are required.
• Cross-Coupling Reactions: The bromomethyl group acts as a handle for further functionalization via Suzuki, Heck, or Buchwald-Hartwig amination reactions.
• Bioconjugation and Probe Synthesis: Useful for creating fluorescent probes, affinity labels, and other bioconjugation reagents for biochemical research.

Basic Information

Product Name	4-(Bromomethyl)-3-Fluorobenzaldehyde
CAS No.	1416980-24-9
Molecular Formula	C8H6BrFO
Molecular Weight	217.04 g/mol
Synonyms	3-Fluoro-4-(bromomethyl)benzaldehyde; 4-Bromomethyl-3-fluorobenzaldehyde; Benzaldehyde, 4-(bromomethyl)-3-fluoro-; (3-Fluoro-4-formylphenyl)methyl bromide
EINECS	Contact for details

Quality Control

Our 4-(Bromomethyl)-3-Fluorobenzaldehyde is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC, GC, NMR, and mass spectrometry to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting cGMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.