Description

2-Chloro-3-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine is a high-value, multi-functional heterocyclic boronic ester building block essential for modern synthetic chemistry. Its core value lies in enabling efficient carbon-carbon bond formation via the Suzuki-Miyaura cross-coupling reaction, a cornerstone of pharmaceutical and advanced materials research. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and organic electronics industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), especially in kinase inhibitor and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific pyridine-based scaffolds.
• Material Science: Serves as a precursor for creating organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs) with tailored electronic properties.
• Cross-Coupling Reactions: Primarily employed in palladium-catalyzed Suzuki-Miyaura couplings to introduce the 2-chloro-3-fluoro-4-pyridyl moiety into complex molecules.
• Chemical Biology & Proteomics: Utilized as a versatile handle for bioconjugation and the development of molecular probes and inhibitors.
• Contract Research & Manufacturing (CRO/CMO): A critical raw material for custom synthesis and scale-up services targeting niche, high-value compounds.

Basic Information

Product Name	2-Chloro-3-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine
CAS No.	1416367-16-2
Molecular Formula	C11H14BClFNO2
Molecular Weight	255.50 g/mol
Synonyms	2-Chloro-3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; (2-Chloro-3-fluoropyridin-4-yl)boronic acid pinacol ester; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-chloro-3-fluoropyridine; 2-Chloro-3-fluoro-4-pyridineboronic acid pinacol ester; 2-Chloro-3-fluoro-4-(pinacolboron)pyridine; CAS 1416367-16-2; 1416367-16-2
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-3-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine is manufactured and tested under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high purity and consistency suitable for demanding research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and when opening the container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.