Description

1H-Imidazole-4-Sulfonyl Chloride Hcl is a high-purity sulfonyl chloride derivative, a key reactive intermediate in modern synthetic chemistry. This compound is essential for introducing the imidazole-4-sulfonyl moiety into target molecules, enabling the development of novel chemical entities. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing potential drug candidates, particularly in medicinal chemistry programs targeting enzyme inhibition.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging its reactive sulfonyl chloride group.
• Peptide Modification & Bioconjugation: Serves as a reagent for selectively modifying amino acid side chains, such as lysine, in peptides and proteins for labeling or functionalization.
• Material Science Research: Employed in the creation of functional polymers, metal-organic frameworks (MOFs), and advanced materials with tailored properties.
• Chemical Probe Development: Utilized in academic and industrial R&D to create specific chemical probes for studying biological pathways and mechanisms.
• Sulfonamide Library Synthesis: A key precursor for high-throughput synthesis of diverse sulfonamide compound libraries for screening in drug discovery.

Basic Information

Item	Detail
Product Name	1H-Imidazole-4-Sulfonyl Chloride Hcl
CAS No.	1416352-08-3
Molecular Formula	C3H4ClN2O2S • HCl
Molecular Weight	215.05 g/mol (for free base: 178.59 g/mol)
Synonyms	1H-Imidazole-4-sulfonyl chloride hydrochloride; Imidazole-4-sulfonyl chloride HCl; 4-Imidazolesulfonyl chloride hydrochloride; 1H-Imidazole-4-sulfonic acid chloride hydrochloride; Imidazole-4-sulfonyl chloride monohydrochloride; 4-Sulfonylchloride imidazole HCl; 1H-Imidazol-4-ylsulfonyl chloride hydrochloride
EINECS	Contact for details

Quality Control

Our 1H-Imidazole-4-Sulfonyl Chloride Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with cGMP, ISO, and other relevant quality standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in its original packaging to prevent degradation. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Solubility	Soluble in polar aprotic solvents (e.g., DMF, DMSO)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.