Description

Gsk2795039 is a potent and selective small molecule inhibitor of NADPH oxidase 2 (NOX2), a key enzyme complex involved in the generation of reactive oxygen species (ROS). This compound is of significant value for research into oxidative stress-related pathways, inflammation, and associated disease models. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on developing novel therapeutics for conditions where NOX2 activity is implicated.

Application

• Biochemical Research: Used as a critical tool compound to selectively inhibit NOX2 activity in in vitro cell-based assays and in vivo studies.
• Pharmacology Studies: Employed to investigate the role of oxidative stress in disease mechanisms, including cardiovascular disorders, neurodegenerative diseases, and chronic inflammation.
• Drug Discovery & Development: Serves as a reference standard or lead compound in screening campaigns and preclinical development for NOX2-targeted therapies.
• Academic Research: Facilitates fundamental research in immunology, neurology, and cell biology to elucidate NOX2 signaling pathways.

Basic Information

Product Name	Gsk2795039
CAS No.	1415925-18-6
Molecular Formula	C₂₀H₂₀N₄O₃S
Molecular Weight	396.46 g/mol
Synonyms	GSK2795039; 2-(2-Chlorophenyl)-4-[3-(dimethylamino)phenyl]-5-methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione; NADPH Oxidase 2 Inhibitor; NOX2 Inhibitor GSK2795039
EINECS	Contact for details

Quality Control

Our Gsk2795039 is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity assessment and spectroscopic methods for structural confirmation, to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert atmosphere for long-term stability. Allow the product to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular weight
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.