Description

(R)-3-Fluoropyrrolidine-1-Sulfonyl Chloride is a high-value, chiral building block and key reagent in modern synthetic chemistry. Its primary value lies in its dual functionality as a sulfonyl chloride and a fluorinated heterocycle, enabling the efficient introduction of the (R)-3-fluoropyrrolidine scaffold—a privileged structure in medicinal chemistry—into target molecules. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients where stereochemistry and fluorine substitution are critical for potency and metabolic stability.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitors, central nervous system (CNS) agents, and antiviral drugs.
• Sulfonamide Library Synthesis: Used in high-throughput and parallel synthesis to create diverse sulfonamide-based compound libraries for drug discovery screening.
• Proteolysis Targeting Chimera (PROTAC) Linker: Employed in the construction of E3 ligase-binding ligands or linkers within bifunctional PROTAC molecules.
• Agrochemical Research: Serves as a building block for developing new herbicides and fungicides with enhanced activity and selectivity.
• Fluorinated Peptidomimetics: Incorporated into peptide analogs to improve bioavailability and resistance to enzymatic degradation.
• Material Science: Potential monomer or cross-linking agent for creating specialized fluorinated polymers with unique surface properties.

Basic Information

Item	Details
Product Name	(R)-3-Fluoropyrrolidine-1-Sulfonyl Chloride
CAS No.	1411774-27-0
Molecular Formula	C4H7ClFNO2S
Molecular Weight	187.62 g/mol
Synonyms	(R)-1-(Chlorosulfonyl)-3-fluoropyrrolidine; (R)-3-Fluoro-1-(sulfonyl chloride)pyrrolidine; (R)-3-Fluoropyrrolidine Sulfonyl Chloride; (3R)-3-Fluoropyrrolidine-1-sulfonyl chloride; (R)-NSC 405124; 3-Fluoropyrrolidine-1-sulfonyl chloride, (R)-; 1-Pyrrolidinesulfonyl chloride, 3-fluoro-, (3R)-
EINECS	Contact for details

Quality Control

Our (R)-3-Fluoropyrrolidine-1-Sulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to ensure enantiomeric purity and NMR for structural confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.