Description

Jnk-In-8 is a potent and selective small molecule inhibitor of c-Jun N-terminal kinase (JNK). This compound is a critical research tool for investigating the JNK signaling pathway, which plays a significant role in cellular stress responses, apoptosis, and inflammation. It is primarily utilized by researchers and scientists in the fields of pharmaceutical development, academic biochemistry, and cell biology for target validation and mechanistic studies.

Application

• Biochemical Research: Used as a selective inhibitor to study the function and regulation of the JNK signaling pathway in vitro.
• Cell-Based Assays: Employed to investigate the role of JNK in cellular processes such as apoptosis, proliferation, and differentiation.
• Drug Discovery: Serves as a reference compound or a starting point for the development of novel therapeutics targeting inflammatory and neurodegenerative diseases.
• Signal Transduction Studies: A key tool for elucidating kinase cascades and cross-talk between different stress-activated pathways.
• Academic & Institutional Laboratories: Essential for basic research in universities and research institutes focusing on molecular biology and pharmacology.

Basic Information

Product Name	Jnk-In-8
CAS No.	1410880-22-6
Molecular Formula	C₂₀H₂₀N₄O₂S
Molecular Weight	380.46 g/mol
Synonyms	JNK-IN-8; JNK Inhibitor VIII; 3-(4-((4-(Morpholinomethyl)phenyl)thio)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 3-[4-[[4-(4-morpholinylmethyl)phenyl]thio]phenyl]-; JNK Inhibitor 8; c-Jun N-terminal Kinase Inhibitor VIII
EINECS	Contact for details

Quality Control

Our Jnk-In-8 is manufactured under strict quality protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry for identity and purity verification. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.