Description

Nexturastat A is a potent and selective small molecule inhibitor of histone deacetylase 6 (HDAC6). This compound matters for researchers and developers as it provides a critical tool for probing HDAC6-specific pathways in cellular processes, offering high selectivity over other HDAC isoforms. It is primarily needed by the pharmaceutical, biotechnology, and life science research sectors for applications in oncology research, neurodegenerative disease studies, and the development of novel epigenetic therapies.

Application

• Epigenetics and Cancer Research: Used as a selective chemical probe to investigate the role of HDAC6 in tumor cell proliferation, metastasis, and apoptosis.
• Neurodegenerative Disease Models: Employed in preclinical studies targeting tauopathy and protein aggregation pathways relevant to Alzheimer's and Parkinson's diseases.
• Immunology and Inflammation Studies: Applied to modulate immune cell function and cytokine production through HDAC6-mediated mechanisms.
• Drug Discovery & Development: Serves as a reference compound or lead structure in high-throughput screening and medicinal chemistry programs for HDAC6 inhibitors.
• Biochemical Assay Development: Utilized as a standard or control in enzymatic assays to validate HDAC6 activity and inhibitor screening platforms.
• Academic Research: Supports fundamental biological research into cytoskeleton dynamics, cell motility, and chaperone function.

Basic Information

Product Name	Nexturastat A
CAS No.	1403783-31-2
Molecular Formula	C₁₉H₂₀N₂O₃
Molecular Weight	324.38 g/mol
Synonyms	Nexturastat A; HDAC6 Inhibitor Nexturastat A; (E)-N-Hydroxy-4-((2-(naphthalen-1-yl)ethyl)amino)benzamide; AGK-7; AGK7; AGK 7; Nexturastat
EINECS	Contact for details

Quality Control

Our Nexturastat A is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity confirmation and NMR for structural verification, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.