Description

Nlg919 CAS NO 1402836-58-1 is a high-purity, small-molecule chemical compound of significant interest in advanced pharmaceutical research and development. Its primary value lies in its role as a potent and selective inhibitor of the enzyme nicotinamide phosphoribosyltransferase (NAMPT), a key regulator of cellular metabolism. This compound is essential for researchers and developers in the life sciences sector, particularly those focused on oncology, metabolic disorders, and aging-related diseases, where modulating NAD+ biosynthesis pathways is a critical therapeutic strategy.

Application

• Pharmaceutical Research: As a reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel NAMPT inhibitors for cancer therapy.
• Preclinical Studies: Utilized in in vitro and in vivo models to investigate the effects of NAD+ depletion on tumor cell viability and metabolism.
• Biochemical Assays: Serves as a critical tool compound in high-throughput screening and enzymatic assays to study NAMPT activity and inhibition kinetics.
• Mechanistic Biology: Employed to explore the role of NAD+-dependent processes such as DNA repair (via PARP enzymes) and cellular signaling (via sirtuins) in disease pathology.
• Academic Research: Used in university and institutional labs for fundamental research into metabolic pathways, cellular energetics, and potential anti-aging interventions.

Basic Information

Product Name	Nlg919
CAS No.	1402836-58-1
Molecular Formula	C₁₉H₁₅N₃O₂
Molecular Weight	317.34 g/mol
Synonyms	Nlg919; NAMPT Inhibitor Nlg919; 2-[[(3-Aminophenyl)methyl]thio]-N-(3-pyridinylmethyl)benzamide; 2-(((3-Aminobenzyl)thio)methyl)-N-(pyridin-3-ylmethyl)benzamide; GNE-617; N-(Pyridin-3-ylmethyl)-2-((3-(aminomethyl)benzyl)thio)benzamide; Benzamide, 2-[[(3-aminophenyl)methyl]thio]-N-(3-pyridinylmethyl)-
EINECS	Contact for details

Quality Control

Our Nlg919 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination, NMR and MS for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to guarantee traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. The compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.