Description

Cdc7-In-7 is a potent and selective small molecule inhibitor of the cell division cycle 7 (Cdc7) kinase, a key regulator of DNA replication initiation. This compound is a critical research tool for investigating cell cycle progression, DNA replication stress, and the development of targeted cancer therapeutics. It is essential for pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on oncology and cell biology.

Application

• Biochemical Research: Used as a selective probe to study the role of Cdc7 kinase in DNA replication and cell cycle checkpoints.
• Oncology Drug Discovery: Serves as a lead compound or reference standard in the development of novel anti-cancer agents targeting DNA replication machinery.
• Mechanistic Studies: Employed in vitro and in cellular assays to elucidate pathways of replication stress response and genomic instability.
• High-Throughput Screening (HTS): Utilized as a control or validation compound in screening campaigns for Cdc7 inhibitors.
• Preclinical Development: Supports pharmacokinetic, pharmacodynamic, and efficacy studies in relevant disease models.

Basic Information

Product Name	Cdc7-In-7
CAS No.	1402059-17-9
Molecular Formula	C₂₀H₂₀N₆O₂
Molecular Weight	376.41 g/mol
Synonyms	CDC7-IN-7; Cdc7 Inhibitor VII; 2-[(3R)-3-Amino-1-piperidinyl]-5-[(4-methyl-1-piperazinyl)sulfonyl]benzothiazole; 2-[(3R)-3-Aminopiperidin-1-yl]-5-[(4-methylpiperazin-1-yl)sulfonyl]-1,3-benzothiazole; BMS-863233; XL413
EINECS	Contact for details

Quality Control

Our Cdc7-In-7 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided, ensuring the material meets the high-purity standards required for research and development. We support compliance with relevant guidelines for research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert conditions for long-term stability. Allow the product to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation. Keep the container sealed and stored in a cool, dry, well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.