Description

Cdc7-In-5 CAS NO 1402057-86-6 is a potent and selective small molecule inhibitor of the cell division cycle 7 (Cdc7) kinase, a key regulator of DNA replication initiation. This compound matters as a critical research tool for investigating cell cycle progression, DNA replication stress, and the development of targeted cancer therapeutics. It is primarily needed by pharmaceutical R&D teams, academic researchers in oncology and cell biology, and biotechnology companies focused on developing novel anti-cancer agents.

Application

• Biochemical Research: Used as a selective probe to study the role of Cdc7 kinase in DNA replication and cell cycle control in vitro.
• Oncology Research: Investigated for its potential to inhibit the proliferation of cancer cells that are dependent on Cdc7 activity.
• Mechanistic Studies: Employed in target validation and pathway analysis to understand replication stress responses and checkpoint signaling.
• Drug Discovery: Serves as a reference compound or lead structure in the development of novel Cdc7-targeted therapeutic candidates.
• Cellular Assays: Used in high-throughput screening (HTS) and functional cellular assays to measure Cdc7 inhibition and downstream effects.

Basic Information

Product Name	Cdc7-In-5
CAS No.	1402057-86-6
Molecular Formula	C₂₀H₂₀N₆O₂
Molecular Weight	376.41 g/mol
Synonyms	Cdc7 Inhibitor V; 2-(3,5-Dimethoxyphenyl)-N-(5-(1-methyl-1H-pyrazol-4-yl)-1,3,4-thiadiazol-2-yl)acetamide; Cdc7 Kinase Inhibitor; DBKIN-5; Cdc7-IN-5
EINECS	Contact for details

Quality Control

Our Cdc7-In-5 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research use. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and batch-specific data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.