Description

Cdc7-In-1 CAS NO 1402055-25-7 is a potent, cell-permeable, and ATP-competitive dual inhibitor of the Cdc7 and Dbf4 (DDK) kinases, which are critical regulators of DNA replication initiation. This compound matters as a valuable research tool for investigating cell cycle progression, DNA replication checkpoints, and the mechanisms underlying genomic instability. It is primarily needed by researchers and pharmaceutical developers in the fields of oncology, molecular biology, and biochemistry for target validation and preclinical studies.

Application

• Biochemical Research: Used as a selective inhibitor to study the function and signaling pathways of the Cdc7/Dbf4 kinase complex in vitro.
• Cell Biology Studies: Employed in cell-based assays to investigate the role of DDK in DNA replication origin firing, S-phase progression, and cell cycle regulation.
• Oncology Research: Serves as a lead compound or tool molecule for exploring novel cancer therapeutic strategies that target DNA replication machinery.
• Mechanistic Studies: Facilitates research into replication stress, checkpoint responses, and the development of chemotherapeutic resistance.
• High-Throughput Screening (HTS): Can be used as a reference standard or positive control in screening campaigns for novel DDK inhibitors.
• Academic & Pharmaceutical R&D: Essential for basic research and drug discovery programs focused on cell cycle proteins as anti-cancer targets.

Basic Information

Product Name	Cdc7-In-1
CAS No.	1402055-25-7
Molecular Formula	C₂₆H₂₈N₈O₃
Molecular Weight	500.56 g/mol
Synonyms	Cdc7 inhibitor 1; Cdc7/Dbf4 Inhibitor; DDK Inhibitor; 5-[(2,4-Dichlorophenyl)methyl]-N-[(1S)-1-(hydroxymethyl)-2-methylpropyl]-1,3-thiazole-2-carboxamide; BMS-863233; XL413; CAS 1402055-25-7; Cdc7 Kinase Inhibitor
EINECS	Contact for details

Quality Control

Our Cdc7-In-1 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and assay results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.