Description

2-Ethynyl-3-Fluoropyridine is a high-value, multi-functional heterocyclic building block featuring both an ethynyl and a fluorine substituent on the pyridine ring. This unique structure makes it a critical intermediate for the synthesis of complex molecules in advanced research and development. It is primarily sought after by pharmaceutical, agrochemical, and materials science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in kinase inhibitor and CNS-active compound research.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Ligand & Catalyst Development: Serves as a precursor for sophisticated ligands in transition metal catalysis and organometallic chemistry.
• Material Science Building Block: Incorporated into the synthesis of advanced polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The ethynyl group is ideal for Sonogashira and other palladium-catalyzed cross-coupling reactions to construct complex molecular architectures.
• Fluorine Chemistry Research: The fluorine atom provides a handle for studying metabolic stability, bioavailability, and intermolecular interactions in new compounds.

Basic Information

Product Name	2-Ethynyl-3-Fluoropyridine
CAS No.	1401685-43-5
Molecular Formula	C7H4FN
Molecular Weight	121.11 g/mol
Synonyms	3-Fluoro-2-ethynylpyridine; 2-Ethynyl-3-fluoropyridine; 3-Fluoropyridin-2-ylacetylene; 2-Pyridinylacetylene, 3-fluoro-; 3-Fluoro-2-pyridinylacetylene
EINECS	Contact for details

Quality Control

Every batch of 2-Ethynyl-3-Fluoropyridine is produced and tested under strict quality management protocols to ensure consistency and purity for research and development applications. Our products undergo rigorous analytical testing, including HPLC, NMR, and GC-MS, to verify identity and purity. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid or crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.