Description

1,1,1-Trifluoro-2-(4-Methylpyridin-2-Yl)Propan-2-Yl Methanesulfonate is a high-value, fluorinated pyridine derivative that serves as a critical building block in advanced organic synthesis. This compound is essential for the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique trifluoromethyl and mesylate leaving group confer desirable biological and physicochemical properties. It is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and anti-infective therapies.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the stability and lipophilicity imparted by the trifluoromethyl group.
• Ligand & Catalyst Precursor: Serves as a precursor for creating specialized ligands in asymmetric catalysis and transition metal complexes.
• Material Science: Employed in the research of advanced fluorinated polymers and functional materials with enhanced chemical resistance and thermal stability.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes in fine chemical production.
• Academic & Industrial R&D: Utilized in exploratory chemistry for method development and the creation of novel chemical entities in research laboratories.

Basic Information

Product Name	1,1,1-Trifluoro-2-(4-Methylpyridin-2-Yl)Propan-2-Yl Methanesulfonate
CAS No.	1396893-44-9
Molecular Formula	C11H12F3NO3S
Molecular Weight	295.28 g/mol
Synonyms	2-(4-Methylpyridin-2-yl)-1,1,1-trifluoropropan-2-yl methanesulfonate; 1,1,1-Trifluoro-2-(4-methyl-2-pyridinyl)-2-propanol methanesulfonate; 2-(4-Methyl-2-pyridyl)-1,1,1-trifluoropropan-2-yl mesylate; 1,1,1-Trifluoro-2-(4-methylpyridin-2-yl)propan-2-yl mesylate; Trifluoromethyl Pyridinyl Propanol Mesylate; TFMPM Intermediate; CAS 1396893-44-9
EINECS	Contact for details

Quality Control

Our 1,1,1-Trifluoro-2-(4-Methylpyridin-2-Yl)Propan-2-Yl Methanesulfonate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request. We support compliance with cGMP and ISO standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.