Description

Mammalian Ste20-Like Protein Kinase 1 Inhibitor CAS NO 1396771-17-7 is a potent and selective small molecule inhibitor designed to target the MST1/STK4 kinase, a key regulator of the Hippo signaling pathway involved in cell proliferation, apoptosis, and organ size control. This compound is essential for researchers and developers in the life sciences sector seeking to modulate this critical pathway for therapeutic discovery and basic biological research. It is primarily utilized in pharmaceutical R&D, academic research, and biotechnology applications focused on oncology, immunology, and regenerative medicine.

Application

• Pharmaceutical Research & Development: Serves as a critical tool compound for target validation and lead optimization in drug discovery programs targeting cancers and inflammatory diseases.
• Academic & Basic Research: Used to elucidate the functional role of the Hippo signaling pathway in cellular processes like apoptosis, proliferation, and differentiation.
• Biochemical Assay Development: Employed as a reference standard in high-throughput screening (HTS) and enzymatic assays to identify and characterize novel MST1 inhibitors.
• Cell Biology Studies: Applied in vitro to study the effects of MST1 inhibition on cell fate decisions, immune cell function, and tissue regeneration models.
• Preclinical Disease Modeling: Utilized in animal models to investigate the therapeutic potential of MST1 pathway modulation in oncology and autoimmune disorders.

Basic Information

Product Name	Mammalian Ste20-Like Protein Kinase 1 Inhibitor
CAS No.	1396771-17-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	MST1 Inhibitor; STK4 Inhibitor; Mammalian STE20-like kinase 1 Inhibitor; Hippo Pathway Inhibitor; CAS 1396771-17-7; 4-(4-(4-(Pyrimidin-2-yl)piperazin-1-yl)phenyl)quinazoline (core structural analog); Protein Kinase MST1 Inhibitor
EINECS	Contact for details

Quality Control

Our Mammalian Ste20-Like Protein Kinase 1 Inhibitor is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and NMR/LC-MS for structural confirmation, to ensure high chemical and biological consistency. Certificates of Analysis (COA) detailing purity, identity, and potency are provided with every shipment to support your research integrity and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. The product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.