Description

Plinabulin CAS NO 1394854-62-6 is a novel, small-molecule investigational compound that functions as a vascular disrupting agent and immunomodulator. Its primary value lies in its dual mechanism of action, targeting both tumor vasculature and immune response pathways, which is of significant interest in oncology research. This product is essential for pharmaceutical R&D teams, academic researchers, and contract research organizations (CROs) focused on developing next-generation cancer therapeutics, particularly for non-small cell lung cancer and chemotherapy-induced neutropenia.

Application

• Oncology Drug Development: Primary active pharmaceutical ingredient (API) in preclinical and clinical-stage research for various solid tumors.
• Mechanistic Studies: Used as a research tool to study vascular disruption and immunogenic cell death (ICD) in cancer models.
• Combination Therapy Research: Investigated in combination with checkpoint inhibitors and other chemotherapeutic agents to enhance anti-tumor efficacy.
• Process Chemistry & Formulation: Serves as a reference standard and starting material for the development of scalable synthesis routes and novel drug formulations.
• Academic Research: Utilized in university and institutional labs for fundamental cancer biology and pharmacology studies.

Basic Information

Product Name	Plinabulin
CAS No.	1394854-62-6
Molecular Formula	C₂₀H₂₀N₄O₂
Molecular Weight	348.40 g/mol
Synonyms	NPI-2358; BPI-2358; (3S,4R)-3-((S)-sec-Butyl)-4-(2,3-dihydro-1H-indol-1-yl)-1-(4-fluorobenzyl)pyrrolidine-2,5-dione; 1H-Indole, 1-[(3S,4R)-3-[(1S)-1-methylpropyl]-2,5-diox-4-(4-fluorobenzyl)-1-pyrrolidinyl]-; Plinabulin (BPI-2358)
EINECS	Contact for details

Quality Control

Our Plinabulin is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for research and development purposes. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to ICH guidelines for stability and impurity characterization, and our quality commitment supports regulatory filings for investigational new drug (IND) applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.