Description

5-Chloro-4-Fluoropyridin-2-Amine CAS NO 1393574-54-3 is a high-purity fluorinated pyridine derivative, a critical building block in modern organic synthesis. Its value lies in its unique halogenated amine structure, which enables precise molecular modifications essential for developing advanced materials and active pharmaceutical ingredients. This compound is primarily needed by research and development chemists, process scale-up teams, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the fluorine and chlorine substituents enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a versatile starting material for creating specialized ligands used in catalytic processes and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of functionalized polymers and advanced organic electronic materials.
• Chemical Biology Probes: Utilized to create tagged molecules for studying biological pathways and protein interactions.
• Custom Synthesis and Contract Manufacturing: A fundamental substrate for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	5-Chloro-4-Fluoropyridin-2-Amine
CAS No.	1393574-54-3
Molecular Formula	C5H4ClFN2
Molecular Weight	146.55 g/mol
Synonyms	2-Amino-5-chloro-4-fluoropyridine; 4-Fluoro-5-chloropyridin-2-amine; 5-Chloro-4-fluoro-2-pyridinamine; 5-Chloro-4-fluoropyridin-2-ylamine; 1393574-54-3; 2-Pyridinamine, 5-chloro-4-fluoro-
EINECS	Contact for details

Quality Control

Every batch of 5-Chloro-4-Fluoropyridin-2-Amine is produced under strict quality management protocols. We guarantee high chemical purity and lot-to-lot consistency, supported by comprehensive analytical testing including HPLC, NMR, and MS. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment. Our quality system is designed to meet the stringent requirements of cGMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.