Description

1-Bromo-3-(2,2-Difluorocyclopropyl)Benzene is a high-value, multi-functional aromatic building block featuring a unique difluorocyclopropyl substituent. This compound is essential for advanced organic synthesis, particularly in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals where the introduction of fluorine atoms and strained ring systems is critical for modulating biological activity and physicochemical properties. It is primarily sought after by research and development chemists, process development teams, and manufacturers in the pharmaceutical, agrochemical, and specialty materials sectors.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, where the difluorocyclopropyl group enhances metabolic stability and bioavailability.
• Ligand and Catalyst Development: Serves as a sophisticated scaffold for creating novel ligands in asymmetric catalysis and organometallic chemistry.
• Material Science Research: Employed in the development of advanced polymers and liquid crystals, where its structure can impart unique electronic and steric properties.
• Fluorine Chemistry Exploration: An important reagent for studying the effects of gem-difluorocyclopropanation on aromatic systems in medicinal and synthetic chemistry.

Basic Information

Item	Details
Product Name	1-Bromo-3-(2,2-Difluorocyclopropyl)Benzene
CAS No.	1393563-14-8
Molecular Formula	C9H7BrF2
Molecular Weight	233.05 g/mol
Synonyms	3-Bromo-1-(2,2-difluorocyclopropyl)benzene; 1-Bromo-3-(2,2-difluorocyclopropyl)benzene; m-Bromo-(2,2-difluorocyclopropyl)benzene; (2,2-Difluorocyclopropyl)-3-bromobenzene; 3-(2,2-Difluorocyclopropyl)phenyl bromide; Benzene, 1-bromo-3-(2,2-difluorocyclopropyl)-; 1393563-14-8
EINECS	Contact for details

Quality Control

Every batch of 1-Bromo-3-(2,2-Difluorocyclopropyl)Benzene is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and scale-up applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by advanced chromatographic and spectroscopic methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong acids and oxidizing agents. The compound is compatible with standard organic solvents but should be handled in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.