Description

Kpt-330 is a high-purity, small molecule pharmaceutical intermediate and research chemical with the CAS registry number 1393477-72-9. This compound is of significant value in medicinal chemistry for the development of novel therapeutic agents targeting specific protein-protein interactions. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in oncology and targeted drug discovery programs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of investigational new drugs, particularly in oncology research.
• Biochemical Research: Used as a potent and selective probe or inhibitor in molecular biology studies to investigate specific biological pathways.
• Preclinical Development: Serves as a critical material for pharmacokinetic, pharmacodynamic, and toxicology studies during drug candidate optimization.
• Chemical Biology: Employed in target identification and validation studies to understand disease mechanisms at a molecular level.
• Reference Standard: Supplied as a certified reference material for analytical method development and quality control in API manufacturing.

Basic Information

Product Name	Kpt-330
CAS No.	1393477-72-9
Molecular Formula	C₂₀H₁₉N₃O₂S
Molecular Weight	365.45 g/mol
Synonyms	Selinexor; KPT-330; (Z)-3-(3,5-Bis(trifluoromethyl)phenyl)-N-((2-(2,5-dimethoxyphenyl)pyridin-3-yl)methyl)acrylamide; CRM1 Inhibitor KPT-330; Selective Inhibitor of Nuclear Export (SINE); Xpovio (Drug Substance); XPOVIO™ API; Antineoplastic Agent KPT330
EINECS	Contact for details

Quality Control

Every batch of Kpt-330 is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) that include data from HPLC, NMR, and MS. Our production adheres to cGMP guidelines where applicable, supporting its use in advanced research and development phases.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator to maintain stability and prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%; Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.