Description

Glucagon Receptor Antagonists-4 CAS NO 1393124-08-7 is a high-purity, non-peptidic small molecule antagonist designed for selective inhibition of the glucagon receptor (GCGR). This compound is critical for advancing research into metabolic disorders, particularly type 2 diabetes, by targeting the glucagon signaling pathway to modulate hepatic glucose production. It is an essential research-grade chemical for pharmaceutical R&D teams, academic institutions, and biotechnology companies focused on developing novel therapeutics for diabetes and related metabolic syndromes.

Application

• Pharmacological Research: A key tool compound for in vitro and in vivo studies investigating glucagon receptor biology and signal transduction.
• Drug Discovery & Development: Serves as a lead compound or reference standard in high-throughput screening (HTS) campaigns and structure-activity relationship (SAR) studies for new antidiabetic agents.
• Metabolic Disease Modeling: Used to establish and validate cellular and animal models of hyperglycemia and impaired glucose homeostasis.
• Mechanism of Action Studies: Enables precise investigation into the role of glucagon receptor antagonism in regulating hepatic glucose output and insulin sensitivity.
• Biochemical Assay Development: Employed as a critical reagent in developing and calibrating competitive binding assays (e.g., fluorescence polarization) and functional assays for GCGR.
• Preclinical Proof-of-Concept: Supports efficacy and safety profiling in preclinical stages of therapeutic development for diabetes and obesity.

Basic Information

Product Name	Glucagon Receptor Antagonists-4
CAS No.	1393124-08-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	GCGR Antagonist-4; Glucagon Receptor Antagonist 4; Glucagon Receptor Antagonists-4; 1393124-08-7; Non-peptidic glucagon receptor antagonist; Small molecule GCGR inhibitor; Antidiabetic research compound; Metabolic disorder research chemical
EINECS	Contact for details

Quality Control

Our Glucagon Receptor Antagonists-4 is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including purity verification by HPLC and structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and relevant analytical data to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under desiccated conditions. Allow the product to equilibrate to room temperature in a dry environment before opening to prevent moisture condensation. The product should be handled in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.