Description

Tetrabenazine-D6 is a deuterium-labeled analog of the vesicular monoamine transporter 2 (VMAT2) inhibitor, tetrabenazine. This stable isotope-labeled compound is essential for precise and reliable quantitative analysis in pharmacokinetic and metabolic studies. It serves as a critical internal standard for researchers and quality control laboratories in the pharmaceutical and biotechnology sectors, ensuring accurate measurement of the parent drug in complex biological matrices.

Application

• Internal Standard for LC-MS/MS: Primary use as a quantitative internal standard in Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) bioanalysis of tetrabenazine.
• Pharmacokinetic Research: Enables accurate determination of drug concentration-time profiles in plasma, serum, and tissue samples during preclinical and clinical studies.
• Metabolite Identification and Profiling: Assists in the identification and quantification of tetrabenazine metabolites using mass spectrometry.
• Drug Metabolism and Pharmacokinetics (DMPK): A vital tool in DMPK studies to understand the absorption, distribution, metabolism, and excretion of tetrabenazine.
• Bioequivalence Studies: Used to ensure analytical method accuracy and precision in studies comparing generic and innovator drug formulations.
• Forensic and Clinical Toxicology: Supports the accurate quantification of tetrabenazine in forensic analysis and therapeutic drug monitoring.

Basic Information

Product Name	Tetrabenazine-D6
CAS No.	1392826-25-3
Molecular Formula	C19H21D6NO3
Molecular Weight	323.46 g/mol
Synonyms	Deuterated Tetrabenazine; Tetrabenazine (hexadeuterated); Tetrabenazine-d6; (3R,11bR)-9,10-Dimethoxy-1,3,4,6,7,11b-hexahydro-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-one-d6; Nitoman-d6; Xenazine-d6; RO 1-9569-d6; TBZ-d6
EINECS	Contact for details

Quality Control

Our Tetrabenazine-D6 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for analytical applications. Each batch is characterized by advanced spectroscopic methods, including NMR and Mass Spectrometry, to confirm structure and deuterium incorporation. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), isotopic enrichment, and other critical parameters is provided with every shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.