Description

3-(Boc-Amino)-4-Trifluoromethylpyridine is a high-purity, protected amine derivative of a trifluoromethyl-substituted pyridine, serving as a critical building block in advanced organic synthesis. Its value lies in the combination of the versatile Boc-protected amino group and the electron-withdrawing, metabolically stable trifluoromethyl moiety, which are essential for modulating the physicochemical properties of target molecules. This intermediate is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the construction of novel active ingredients, particularly in medicinal chemistry for drug discovery programs.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), especially in kinase inhibitor and central nervous system (CNS) drug discovery.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of functionalized polymers and advanced organic materials with tailored electronic properties.
• Peptidomimetics and Bio-conjugation: The Boc-protected amine is a standard handle for introducing the pyridine-trifluoromethyl pharmacophore into peptide backbones or for bioconjugation strategies.
• Chemical Biology Probes: Utilized to create molecular probes for studying enzyme function and biological pathways.

Basic Information

Product Name	3-(Boc-Amino)-4-Trifluoromethylpyridine
CAS No.	1392804-92-0
Molecular Formula	C11H13F3N2O2
Molecular Weight	262.23 g/mol
Synonyms	4-(Trifluoromethyl)pyridin-3-amine, N-Boc derivative; tert-Butyl [4-(trifluoromethyl)pyridin-3-yl]carbamate; 3-[(tert-Butoxycarbonyl)amino]-4-(trifluoromethyl)pyridine; N-Boc-3-amino-4-trifluoromethylpyridine; 3-(Boc-amino)-4-(trifluoromethyl)pyridine; Boc-3-A-4-TFP; 3-((tert-Butoxycarbonyl)amino)-4-(trifluoromethyl)pyridine; 3-Amino-4-trifluoromethylpyridine N-Boc protected
EINECS	Contact for details

Quality Control

Our 3-(Boc-Amino)-4-Trifluoromethylpyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with the standards expected for GMP-grade intermediates used in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep the container tightly sealed in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.