Description

Lys05 CAS NO 1391426-24-6 is a potent and selective small molecule inhibitor of lysosomal function, specifically targeting the vacuolar-type H+-ATPase (V-ATPase). This compound is of significant value in biochemical and pharmacological research for its ability to induce lysosomal membrane permeabilization and modulate autophagy pathways. It is primarily needed by researchers in the fields of oncology, neurodegenerative disease, and cell biology for investigating lysosome-dependent cell death mechanisms and developing novel therapeutic strategies.

Application

• Biomedical Research: A critical tool for studying autophagy, lysosomal biology, and their roles in cancer, aging, and metabolic disorders.
• Oncology Studies: Used to investigate lysosome-mediated cell death (LCD) as a potential mechanism for overcoming drug resistance in various cancer cell lines.
• Neurodegenerative Disease Models: Employed in research on Alzheimer's, Parkinson's, and other diseases where lysosomal dysfunction is implicated.
• Pharmacology & Drug Discovery: Serves as a reference compound for screening and developing novel V-ATPase inhibitors and autophagy modulators.
• Cell Signaling Pathways: Utilized to dissect the crosstalk between lysosomal activity, mTOR signaling, and apoptosis.
• In Vitro & In Vivo Studies: Applicable in both cell culture experiments and animal model research to validate therapeutic hypotheses.

Basic Information

Product Name	Lys05
CAS No.	1391426-24-6
Molecular Formula	C₂₀H₂₀N₄O₃
Molecular Weight	364.40 g/mol
Synonyms	Lys05; (E)-N'-(4-(tert-Butyl)phenyl)-N-hydroxy-2-(quinolin-8-yloxy)acetimidamide; V-ATPase Inhibitor Lys05; Lysosomal Inhibitor Lys05; Autophagy Inhibitor Lys05; 8-Quinolinol, 2-[[(1E)-N-hydroxy-2-[[4-(1,1-dimethylethyl)phenyl]amino]-2-oxoethylidene]amino]-; 1391426-24-6
EINECS	Contact for details

Quality Control

Our Lys05 is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and NMR for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert atmosphere for long-term stability. For short-term use, the product may be stored at 2-8°C. Keep the container sealed in a dry and well-ventilated place. Allow the vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.