Description

n-[(2R)-2-Acetyl-1,2,3,4-Tetrahydro-5,8-Dimethoxy-2-Naphthalenyl]-Acetamide-13C is a stable isotope-labeled compound, specifically a carbon-13 (13C) labeled derivative, designed for advanced research and analytical applications. This high-purity material serves as a critical internal standard and tracer in quantitative mass spectrometry, enabling precise metabolic and pharmacokinetic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on drug discovery and development.

Application

• Internal Standard for LC-MS/MS: Essential for accurate quantification in bioanalytical methods for drug metabolism and pharmacokinetics (DMPK) studies.
• Metabolic Pathway Tracing: Used as a tracer to investigate the metabolic fate and biotransformation pathways of pharmaceutical compounds in vitro and in vivo.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of process-related impurities and degradants during drug development.
• Stable Isotope Dilution Assay (SIDA): Provides high accuracy and precision in quantitative analysis, minimizing matrix effects and variability.
• Reference Material for NMR Spectroscopy: The 13C label provides a distinct signal for structural elucidation and confirmation studies using nuclear magnetic resonance.
• Preclinical and Clinical Research: Supports critical studies in early-stage drug development, from lead optimization to first-in-human trials.

Basic Information

Product Name	n-[(2R)-2-Acetyl-1,2,3,4-Tetrahydro-5,8-Dimethoxy-2-Naphthalenyl]-Acetamide-13C
CAS No.	1391067-98-3
Molecular Formula	C16H21NO4 (13C1)
Molecular Weight	291.34 g/mol (for 13C1 labeled form)
Synonyms	(2R)-2-Acetamido-2-acetyl-5,8-dimethoxy-1,2,3,4-tetrahydronaphthalene-13C; Acetamide-13C, N-[(2R)-2-acetyl-1,2,3,4-tetrahydro-5,8-dimethoxy-2-naphthalenyl]-; 5,8-Dimethoxy-2-tetralone-derived Acetamide-13C; 13C-Labeled Tetralone Acetamide; Stable Isotope-Labeled Pharmaceutical Intermediate; Carbon-13 Labeled Acetamide Derivative
EINECS	Contact for details

Quality Control

Every batch of our n-[(2R)-2-Acetyl-1,2,3,4-Tetrahydro-5,8-Dimethoxy-2-Naphthalenyl]-Acetamide-13C is manufactured and analyzed under strict quality systems to ensure the highest isotopic and chemical purity required for sensitive analytical applications. Our products undergo rigorous quality testing, including NMR and HPLC-MS, to confirm identity, isotopic enrichment (typically >99 atom % 13C), and chemical purity. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C
Chemical Purity (by 1H NMR)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.