Description

5-Chloro-1,2-Dihydro-4-Methoxy-2-Oxo-3-Pyridinecarbonitrile-13C3 is a stable isotope-labeled analog of a key pyridine derivative, where three carbon atoms are replaced with the carbon-13 isotope. This compound is of critical importance for use as an internal standard in quantitative mass spectrometry, enabling highly accurate and sensitive analytical measurements. It is primarily needed by pharmaceutical research and development laboratories, contract research organizations (CROs), and analytical testing facilities engaged in drug metabolism and pharmacokinetics (DMPK) studies, bioanalytical method development, and impurity profiling.

Application

• Internal Standard for LC-MS/MS: Essential for the precise quantification of its non-labeled counterpart in complex biological matrices like plasma, serum, and urine.
• Drug Metabolism Studies (DMPK): Used to track and quantify drug molecules and their metabolites during preclinical and clinical research, improving data reliability.
• Bioanalytical Method Development: Serves as a critical reference material for validating robust, sensitive, and accurate HPLC and mass spectrometry methods.
• Impurity Profiling and Degradation Studies: Aids in the identification and quantification of process-related impurities and degradation products in active pharmaceutical ingredients (APIs).
• Pharmacokinetic/Pharmacodynamic (PK/PD) Modeling: Provides the high-fidelity data required for accurate modeling of drug absorption, distribution, metabolism, and excretion.
• Stable Isotope Labeling Research: Used as a building block or reference compound in research involving isotopic labeling for mechanistic studies.

Basic Information

Product Name	5-Chloro-1,2-Dihydro-4-Methoxy-2-Oxo-3-Pyridinecarbonitrile-13C3
CAS No.	1391054-70-8
Molecular Formula	C413C3H5ClN2O2
Molecular Weight	Contact for details
Synonyms	5-Chloro-4-methoxy-2-oxo-1,2-dihydropyridine-3-carbonitrile-13C3; 5-Chloro-1,2-dihydro-4-methoxy-2-oxo-3-cyanopyridine-13C3; 3-Cyano-5-chloro-4-methoxy-2(1H)-pyridinone-13C3; 5-Chloro-4-methoxy-2-oxo-1,2-dihydro-3-pyridinecarbonitrile-13C3; 13C3-Labeled 5-Chloro-1,2-dihydro-4-methoxy-2-oxo-3-pyridinecarbonitrile; [13C3]-5-Chloro-4-methoxy-2-oxo-1,2-dihydropyridine-3-carbonitrile
EINECS	Contact for details

Quality Control

Our isotope-labeled compounds are produced and tested under strict quality management systems to ensure the highest standards of isotopic purity and chemical purity, which are critical for accurate analytical results. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and LC-MS. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment, chemical purity, and analytical data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 99 atom % 13C
Isotopic Enrichment	≥ 99% 13C3
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.