Description

Diacerein-13C6 is a stable isotope-labeled analog of the active metabolite of diacerein, where six carbon atoms are replaced with the carbon-13 isotope. This compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy and reliability in analytical measurements. It is a critical tool for researchers and quality control laboratories in the pharmaceutical and biotechnology sectors, particularly for pharmacokinetic studies, drug metabolism research, and ensuring batch-to-batch consistency of diacerein-based therapeutics.

Application

• Primary use as an Internal Standard for LC-MS/MS in bioanalytical method development and validation.
• Quantification of diacerein and its metabolite rhein in complex biological matrices (e.g., plasma, serum, urine) for pharmacokinetic (PK) and bioequivalence studies.
• High-precision analysis in drug metabolism and disposition (DMPK) research.
• Quality control and impurity profiling in pharmaceutical manufacturing of diacerein API and finished dosage forms.
• Supporting regulatory submissions to agencies like the FDA and EMA by providing definitive analytical data.
• Use in clinical research to monitor drug levels and metabolic pathways with high specificity.

Basic Information

Product Name	Diacerein-13C6
CAS No.	1391052-74-6
Molecular Formula	C19H8O6-13C6
Molecular Weight	~ 374.3 g/mol (Contact for exact value)
Synonyms	1,8-Diacetoxy-3-carboxy-9,10-dioxo-9,10-dihydroanthracene-13C6
Diacetylrhein-13C6
4,5-Bis(acetyloxy)-9,10-dioxo-2-anthracenecarboxylic Acid-13C6
Diacerein (13C6)
ART-13C6 (Artrodar-13C6)
Diacetyl Rhein-13C6
Stable Isotope-Labeled Diacerein (13C6)
EINECS	Contact for details

Quality Control

Every batch of Diacerein-13C6 is manufactured and tested under strict quality systems to meet the exacting requirements of analytical and research applications. Our products undergo rigorous quality testing, including isotopic purity and chemical purity assessment by advanced techniques like HPLC and NMR, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing batch-specific results for isotopic enrichment, chemical purity, and identity are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. Handle under an inert atmosphere if prolonged exposure is anticipated during use.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0% (chemical purity)
Isotopic Purity	≥ 99 atom % 13C (by MS)
Water Content (KF)	≤ 0.5% w/w
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.