Description

Sulfisoxazole-D4 is a deuterated analog of the sulfonamide antibiotic Sulfisoxazole, specifically labeled with four deuterium atoms. This stable isotope-labeled compound is an essential internal standard for accurate quantitative analysis in mass spectrometry-based methods, ensuring precise and reliable measurement of the parent drug. It is primarily required by pharmaceutical research laboratories, contract research organizations (CROs), and analytical testing facilities engaged in pharmacokinetic studies, bioequivalence testing, and drug metabolism and disposition (DMPK) research.

Application

• Internal Standard for LC-MS/MS: Serves as a critical reference compound for the quantitative analysis of Sulfisoxazole in complex biological matrices such as plasma, serum, and urine.
• Pharmacokinetic and Bioanalytical Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in clinical and preclinical research.
• Drug Metabolism Research (DMPK): Used to investigate metabolic pathways and identify metabolites without interference from the analyte.
• Quality Control and Method Validation: Essential for developing, validating, and ensuring the accuracy and reproducibility of analytical methods in GLP/GMP environments.
• Veterinary Pharmaceutical Analysis: Applied in residue testing and pharmacokinetic studies of sulfonamide antibiotics in animals.
• Forensic and Anti-Doping Analysis: Supports confirmatory testing protocols requiring high specificity and accuracy.

Basic Information

Product Name	Sulfisoxazole-D4
CAS No.	1388717-81-4
Molecular Formula	C11H9D4N3O3S
Molecular Weight	271.33 g/mol (approx.)
Synonyms	5-(3,4-Dimethyl-1H-pyrazol-1-yl)sulfanilamide-d4; 4-Amino-N-(3,4-dimethyl-1H-pyrazol-1-yl)benzenesulfonamide-d4; Sulfisoxazole (phenyl-d4); Sulfafurazole-d4; Gantrisin-d4; N1-(3,4-Dimethyl-5-isoxazolyl)sulfanilamide-d4; [phenyl-d4]-Sulfisoxazole; Stable Isotope Labeled Sulfisoxazole
EINECS	Contact for details

Quality Control

Our Sulfisoxazole-D4 is manufactured under strict quality systems to ensure the high chemical purity and isotopic enrichment required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic purity (atom % D), chemical purity (by HPLC), and identity confirmation (by NMR and MS). We adhere to relevant industry standards for stable isotope-labeled compounds to guarantee reliable performance and traceability in your analytical workflows.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term stability, consider storage at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity	≥98.0 atom % D
Chemical Purity	≥95.0% (by NMR)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.