Description

1-[6-Bromo-3-Fluoro-4-(Triethylsilyl)-2-Pyridinyl]Ethanone is a high-value, multi-functional organosilicon building block designed for advanced synthetic chemistry. This compound is critical for researchers and process chemists developing novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique halogenated and silylated pyridine core enables precise molecular construction. It is primarily utilized in the pharmaceutical, agrochemical, and specialty chemical industries for applications such as cross-coupling reactions and the synthesis of complex heterocyclic systems.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of next-generation pesticides and herbicides, leveraging its halogenated structure for bioactivity.
• Cross-Coupling Reactions: Serves as a versatile substrate in palladium-catalyzed reactions like Suzuki, Stille, and Negishi couplings due to the reactive bromo and silyl groups.
• Material Science Research: Employed in the development of organic electronic materials and ligands for catalytic systems.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and reference standards.

Basic Information

Product Name	1-[6-Bromo-3-Fluoro-4-(Triethylsilyl)-2-Pyridinyl]Ethanone
CAS No.	1387561-10-5
Molecular Formula	C15H23BrFNOSi
Molecular Weight	360.34 g/mol
Synonyms	1-(6-Bromo-3-fluoro-4-(triethylsilyl)pyridin-2-yl)ethanone; 2-Acetyl-6-bromo-3-fluoro-4-(triethylsilyl)pyridine; Ethanone, 1-[6-bromo-3-fluoro-4-(triethylsilyl)-2-pyridinyl]-; 1387561-10-5; 6-Bromo-3-fluoro-4-(triethylsilyl)-2-acetylpyridine
EINECS	Contact for details

Quality Control

Our production of 1-[6-Bromo-3-Fluoro-4-(Triethylsilyl)-2-Pyridinyl]Ethanone adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for your critical R&D and scale-up processes. Each lot is characterized by advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment, supporting compliance with cGMP and ICH guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.