Description

2-Bromo-5-Fluoro-4-(Triethylsilyl)Pyridine is a high-value, organosilicon-protected pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both bromo and fluoro substituents alongside a triethylsilyl protecting group, makes it indispensable for constructing complex molecular architectures with precise regiochemistry. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system and oncology.
• Agrochemical Synthesis: Used in the development of new-generation herbicides, fungicides, and insecticides that require fluorinated and halogenated pyridine cores.
• Material Science Research: Employed in the creation of organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs) due to its functionalized aromatic system.
• Cross-Coupling Reactions: The bromine atom serves as an excellent handle for Suzuki, Stille, and Negishi cross-coupling reactions to form biaryl systems.
• Protecting Group Strategy: The triethylsilyl (TES) group can be used to protect specific sites on the pyridine ring during multi-step synthetic sequences, allowing for selective functionalization.
• Ligand Preparation: Acts as a starting material for synthesizing novel nitrogen-containing ligands used in catalysis and coordination chemistry.

Basic Information

Product Name	2-Bromo-5-Fluoro-4-(Triethylsilyl)Pyridine
CAS No.	1387561-09-2
Molecular Formula	C13H21BrFNSi
Molecular Weight	318.30 g/mol
Synonyms	4-(Triethylsilyl)-2-bromo-5-fluoropyridine; 2-Bromo-5-fluoro-4-triethylsilylpyridine; 5-Fluoro-2-bromo-4-(triethylsilyl)pyridine; Pyridine, 2-bromo-5-fluoro-4-(triethylsilyl)-; TES-protected 2-bromo-5-fluoropyridine; 2-Br-5-F-4-TES-Pyridine; 1387561-09-2
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-5-Fluoro-4-(Triethylsilyl)Pyridine is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for research and scale-up applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, GC, NMR, and LC-MS is supplied with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is sensitive to strong bases and should be kept away from such materials. For long-term storage, consider maintaining under an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.