Description

Dyrks-In-1 CAS NO 1387090-01-8 is a potent and selective small molecule inhibitor of the DYRK1A (Dual-specificity tyrosine-regulated kinase 1A) family of kinases. This compound is a critical research tool for investigating cellular signaling pathways related to cell cycle control, neuronal development, and gene transcription. It is primarily utilized by researchers and developers in the pharmaceutical and biotechnology sectors for target validation, mechanism-of-action studies, and as a lead compound in drug discovery programs focused on neurodegenerative diseases, diabetes, and cancer.

Application

• Biochemical Research: Used as a selective inhibitor to study the physiological and pathological roles of DYRK1A and related kinases in cellular assays.
• Drug Discovery & Development: Serves as a key pharmacological tool for target validation and as a starting point for the design of novel therapeutic agents.
• Neuroscience Research: Investigated in models of neurodegenerative disorders, such as Alzheimer's and Down syndrome, where DYRK1A dysregulation is implicated.
• Oncology Research: Explored for its effects on cell proliferation and survival in various cancer cell lines, given the role of DYRK kinases in cell cycle progression.
• Diabetes Research: Applied in studies examining pancreatic β-cell function and replication, areas where DYRK1A inhibition has shown potential.
• Academic & Institutional Research: Supplied to universities and research institutes for fundamental studies in molecular biology and signal transduction.

Basic Information

Product Name	Dyrks-In-1
CAS No.	1387090-01-8
Molecular Formula	C₁₉H₁₇N₅O₂
Molecular Weight	347.37 g/mol
Synonyms	DYRKs-IN-1; DYRK1A Inhibitor; 1H-Pyrrolo[2,3-b]pyridine derivative; DYRK inhibitor; 5-(4-(4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1H-pyrazol-1-yl)-6-morpholinopyridin-2-yl)-1H-pyrrolo[2,3-b]pyridine; Research Compound 1387090-01-8; Kinase Inhibitor DYRKs-IN-1
EINECS	Contact for details

Quality Control

Every batch of Dyrks-In-1 is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and consistency for research applications. Standard quality control includes HPLC purity analysis, NMR and MS confirmation of structure, and determination of residual solvents and water content. A detailed Certificate of Analysis (COA) is supplied with each shipment, and custom purity grades or analytical packages are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥95% (Area %)
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.