Description

(1α,1'S,4β)-Lanabecestat CAS NO 1384082-96-5 is a high-purity, small molecule compound belonging to the class of β-secretase (BACE) inhibitors. This compound is of significant interest in pharmaceutical research and development for its potential role in targeting neurodegenerative pathways. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of novel therapeutics for Alzheimer's disease and related neurological conditions.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in preclinical and clinical studies for Alzheimer's disease.
• Biochemical Assay Development: Used as a specific inhibitor to study the enzymatic activity and inhibition kinetics of the β-secretase 1 (BACE1) enzyme in vitro.
• Mechanism of Action Studies: Employed in cellular and animal models to investigate the pathophysiology of amyloid-beta plaque formation and its modulation.
• Drug Discovery Screening: Acts as a critical compound in high-throughput screening (HTS) campaigns to identify and validate new therapeutic candidates targeting BACE.
• Analytical Method Development: Utilized as a certified reference material (CRM) for developing and validating sensitive analytical methods like HPLC and LC-MS for pharmacokinetic studies.

Basic Information

Product Name	(1α,1'S,4β)-Lanabecestat
CAS No.	1384082-96-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Lanabecestat; AZD3293; LY3314814; (1S,4S)-4-[[(3S)-3-Amino-1-(cyclohexylmethyl)-2,3-dihydro-1H-indol-5-yl]oxy]-1-methylcyclohexanecarboxylic acid; BACE Inhibitor LY3314814; β-secretase 1 Inhibitor AZD3293
EINECS	Contact for details

Quality Control

Our (1α,1'S,4β)-Lanabecestat is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical research materials. Certificates of Analysis (COA) with detailed chromatographic data (HPLC) and spectroscopic confirmation are provided to support your regulatory and research documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.