Description

2-Chloro-4-Fluoropyridine-3-Boronic Acid is a high-value, multi-functional boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its core value lies in enabling efficient cross-coupling reactions, particularly the Suzuki-Miyaura reaction, to construct complex heterocyclic scaffolds. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients, including potential drug candidates and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds containing fluorinated pyridine motifs.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides with improved efficacy and selectivity.
• Material Science: Employed in the creation of advanced organic electronic materials, such as ligands for catalysts or components in organic light-emitting diodes (OLEDs).
• Chemical Biology & Medicinal Chemistry: Serves as a versatile handle for bioconjugation and the development of molecular probes and diagnostic tools.
• Cross-Coupling Reactions: Primarily utilized in palladium-catalyzed Suzuki-Miyaura couplings to form carbon-carbon bonds, enabling the modular construction of complex molecules.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	2-Chloro-4-Fluoropyridine-3-Boronic Acid
CAS No.	1383970-43-1
Molecular Formula	C5H4BClFNO2
Molecular Weight	175.36 g/mol
Synonyms	(2-Chloro-4-fluoropyridin-3-yl)boronic acid; 2-Chloro-4-fluoro-3-pyridineboronic acid; 3-Borono-2-chloro-4-fluoropyridine; 2-Chloro-4-fluoropyridine-3-boronic acid pinacol ester (common derivative); 2-Chloro-4-fluoro-3-pyridinylboronic acid; Boronic acid, B-(2-chloro-4-fluoro-3-pyridinyl)-; 1383970-43-1; 2-Chloro-4-fluoro-3-pyridineboronic acid
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-4-Fluoropyridine-3-Boronic Acid undergoes rigorous analytical testing to ensure it meets the high-purity standards required for sensitive cross-coupling applications. Our quality assurance protocol includes advanced chromatographic and spectroscopic methods. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.