Description

Tropifexor CAS NO 1383816-29-2 is a potent and selective non-bile acid FXR (farnesoid X receptor) agonist, representing a significant advancement in the development of targeted metabolic and liver disease therapeutics. Its high selectivity and favorable pharmacokinetic profile make it a critical intermediate and active pharmaceutical ingredient (API) for research and pharmaceutical manufacturing. This compound is essential for organizations engaged in the development of novel treatments for non-alcoholic steatohepatitis (NASH), primary biliary cholangitis (PBC), and other metabolic disorders.

Application

• Pharmaceutical API Synthesis: Serves as the core active ingredient in the formulation of clinical and commercial drug products targeting FXR.
• Preclinical & Clinical Research: Used as a reference standard and investigational compound in metabolic disease research, pharmacokinetic, and pharmacodynamic studies.
• Non-Alcoholic Steatohepatitis (NASH) Drug Development: A key candidate for developing therapies aimed at reducing liver inflammation and fibrosis.
• Metabolic Syndrome Therapeutics: Employed in research programs targeting dyslipidemia, insulin resistance, and related metabolic pathways.
• Cholestatic Liver Disease Treatment: Investigated for use in conditions like primary biliary cholangitis (PBC) due to its role in bile acid regulation.
• Biochemical Tool Compound: Utilized in vitro and in vivo to study FXR receptor biology and signal transduction mechanisms.

Basic Information

Product Name	Tropifexor
CAS No.	1383816-29-2
Molecular Formula	C27H24F3N3O4S
Molecular Weight	543.56 g/mol
Synonyms	LJN452; LJN-452; (1R,2S)-2-(3-((2-Chloro-4-((R)-1-(cyclopropanecarbonyl)pyrrolidin-3-yloxy)phenyl)carbamoyl)-5-fluorophenyl)cyclopropanecarboxylic acid; Tropifexor (LJN452); FXR Agonist LJN452; 2-[3-[[2-Chloro-4-[(3R)-1-(cyclopropanecarbonyl)pyrrolidin-3-yl]oxy-phenyl]carbamoyl]-5-fluoro-phenyl]cyclopropane-1-carboxylic acid
EINECS	Contact for details

Quality Control

Our Tropifexor is manufactured under strict quality management systems to ensure it meets the exacting standards required for pharmaceutical research and development. Each batch undergoes comprehensive analytical testing, including HPLC for purity and assay, identification by spectroscopic methods (IR, NMR, MS), and stringent control of related substances and residual solvents. A Certificate of Analysis (COA) documenting full compliance with agreed specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Assay (HPLC)	97.0% - 102.0%
Single Unknown Impurity	≤0.5%
Total Impurities	≤2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.