Description

Vps34-In-1 is a potent and selective small-molecule inhibitor of the class III phosphoinositide 3-kinase, Vps34. This compound is a critical research tool for investigating the role of Vps34 in cellular processes such as autophagy, vesicular trafficking, and signaling pathways. It is essential for academic and pharmaceutical researchers focused on oncology, neurodegenerative diseases, and metabolic disorders. The high-purity material ensures reliable and reproducible experimental results in biochemical and cellular assays.

Application

• Biochemical Research: Used as a selective inhibitor to study Vps34 kinase activity and its role in PI3P production in in vitro kinase assays.
• Cell Biology Studies: Essential for probing the function of Vps34 in cellular autophagy, endosomal sorting, and phagosome maturation.
• Drug Discovery & Target Validation: Serves as a key pharmacological tool for validating Vps34 as a therapeutic target in cancer and other diseases.
• Signal Transduction Research: Investigates the interplay between Vps34 and other signaling pathways, such as mTOR and growth factor receptors.
• Academic & Pharmaceutical R&D: A standard reference compound in high-throughput screening (HTS) campaigns and mechanism-of-action studies.

Basic Information

Product Name	Vps34-In-1
CAS No.	1383716-33-3
Molecular Formula	C₂₀H₂₀N₆O₂
Molecular Weight	376.42 g/mol
Synonyms	Vps34-IN-1; VPS34-IN-1; Vps34 Inhibitor 1; 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 1-(2,3-dihydro-1,4-benzodioxin-6-yl)-N-(4-morpholinylphenyl)-; UNII-8J7C5K3Q0F; 8J7C5K3Q0F; 1-(2,3-Dihydro-1,4-benzodioxin-6-yl)-N-(4-morpholinophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
EINECS	Contact for details

Quality Control

Our Vps34-In-1 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade standards. Our quality commitment supports reproducible scientific discovery.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. The product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to warm to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.