Description

2-Trifluoromethyl-Pyridine-3-Boronic Acid Pinacol Ester is a high-value organoboron building block essential for modern synthetic chemistry, particularly in cross-coupling reactions. Its core value lies in enabling the efficient and precise construction of complex molecules containing the pharmacologically important trifluoromethylpyridine scaffold. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating new active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, especially those targeting central nervous system (CNS) disorders, inflammation, and infectious diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the trifluoromethyl group's ability to enhance biological activity and metabolic stability.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile boronic ester reagent for forming carbon-carbon bonds between the pyridine ring and various aryl or heteroaryl halides, a cornerstone reaction in medicinal chemistry.
• Material Science Research: Employed in the development of novel organic electronic materials, ligands for catalysts, and advanced polymers where the pyridine and trifluoromethyl motifs impart specific electronic or physical properties.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Utilized as a linker or component in the design of bifunctional molecules for targeted protein degradation, a cutting-edge therapeutic modality.

Basic Information

Product Name	2-Trifluoromethyl-Pyridine-3-Boronic Acid Pinacol Ester
CAS No.	1383625-22-6
Molecular Formula	C13H15BF3NO2
Molecular Weight	285.07 g/mol
Synonyms	2-(Trifluoromethyl)pyridine-3-boronic acid pinacol ester; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)pyridine; 2-(Trifluoromethyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 2-Trifluoromethyl-3-pyridineboronic acid pinacol ester; Pinacol 2-(trifluoromethyl)pyridin-3-ylboronate; 3-Borono-2-trifluoromethylpyridine pinacol ester
EINECS	Contact for details

Quality Control

Every batch of 2-Trifluoromethyl-Pyridine-3-Boronic Acid Pinacol Ester is produced and tested under strict quality management protocols to ensure consistency and reliability for critical R&D and scale-up processes. Our standard grade meets high-purity requirements typical for advanced synthetic intermediates. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.