Description

Cabazitaxel-D6 is a deuterium-labeled analog of the potent chemotherapeutic agent Cabazitaxel, serving as a critical internal standard for precise bioanalytical quantification. This high-purity reference material is essential for ensuring accuracy and reliability in pharmacokinetic and metabolic studies, where exact measurement is paramount. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers involved in advanced drug development and regulatory compliance.

Application

• Internal Standard for LC-MS/MS: Serves as a stable isotope-labeled internal standard in Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) for the quantitative analysis of Cabazitaxel in biological matrices (e.g., plasma, serum).
• Drug Metabolism and Pharmacokinetics (DMPK): Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical studies.
• Bioanalytical Method Development and Validation: Critical for developing, validating, and ensuring the robustness and reproducibility of analytical methods according to FDA, EMA, and ICH guidelines.
• Clinical Trial Support: Provides reliable quantification of Cabazitaxel levels in patient samples during clinical trials to establish therapeutic windows and safety profiles.
• Impurity Profiling and Degradation Studies: Used as a reference to identify and quantify potential deuterated impurities or degradation products in drug substance and product analysis.
• Metabolite Identification: Aids in the structural elucidation of Cabazitaxel metabolites by providing a known mass shift reference in mass spectrometric analysis.

Basic Information

Product Name	Cabazitaxel-D6
CAS No.	1383561-29-2
Molecular Formula	C45H57D6NO14
Molecular Weight	835.99 g/mol (deuterated form)
Synonyms	Cabazitaxel-d6; (1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-(Acetyloxy)-15-{[(2R,3S)-3-{[(tert-butoxy)carbonyl]amino}-2-hydroxy-3-phenylpropanoyl]oxy}-1-hydroxy-9,12-dimethoxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.0³,¹⁰.0⁴,⁷]heptadec-13-en-2-yl (2R,3S)-3-amino-2-hydroxy-3-phenylpropanoate-d6; XRP6258-d6; Jevtana-d6
EINECS	Contact for details

Quality Control

Every batch of Cabazitaxel-D6 is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive bioanalytical applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as isotopic purity, chemical purity (by HPLC), and residual solvent content. Our quality commitment aligns with the standards expected for pharmaceutical reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (Deuterium Incorporation)	≥99.0 atom % D
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.