Description

Usp7-In-1 CAS NO 1381291-36-6 is a potent and selective small molecule inhibitor of the Ubiquitin Specific Protease 7 (USP7), a key deubiquitinating enzyme involved in critical cellular pathways. This compound is a vital research tool for investigating the role of USP7 in oncology, neurodegenerative diseases, and immune regulation. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on targeted cancer therapy and drug discovery.

Application

• Oncology Research: Used to study USP7's role in stabilizing tumor suppressors (e.g., p53) and oncogenes, aiding in the development of novel cancer therapeutics.
• Drug Discovery Screening: Serves as a reference compound and positive control in high-throughput screening assays for identifying new USP7 inhibitors.
• Epigenetics & Cell Signaling Studies: A tool for dissecting the impact of deubiquitination on histone modification, DNA damage response, and Wnt/β-catenin signaling pathways.
• Neurodegenerative Disease Models: Applied in research exploring the connection between USP7, protein aggregation, and diseases like Alzheimer's and Parkinson's.
• Immunology Research: Used to investigate T-cell activation and immune checkpoint regulation mediated by USP7 activity.
• Chemical Biology & Proteomics: Employed in activity-based protein profiling and target engagement studies to understand USP7 interactomes.

Basic Information

Product Name	Usp7-In-1
CAS No.	1381291-36-6
Molecular Formula	C₂₀H₂₀N₄O₃S
Molecular Weight	396.46 g/mol
Synonyms	USP7 Inhibitor I; USP7-IN-1; 1-(4-(Benzyloxy)phenyl)-3-(4-((4-methylpiperazin-1-yl)sulfonyl)phenyl)thiourea; HAUSP Inhibitor; P5091; P005091; P-5091; Ubiquitin Specific Protease 7 Inhibitor
EINECS	Contact for details

Quality Control

Our Usp7-In-1 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing lot-specific results are provided to ensure reproducibility and reliability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert atmosphere for long-term stability. The compound is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.