Description

(4-(Trifluoromethyl)Pyridin-3-Yl)Methanamine Dihydrochloride is a high-purity, organofluorine building block essential for modern pharmaceutical and agrochemical research. Its value lies in the unique properties imparted by the trifluoromethylpyridine scaffold, which is critical for modulating the bioavailability, metabolic stability, and binding affinity of novel compounds. This advanced intermediate is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research, where the trifluoromethyl group enhances lipophilicity and metabolic stability.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the pyridine core for effective biological activity.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of functionalized polymers and advanced organic electronic materials.
• Chemical Biology Probes: Utilized to create labeled compounds and molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	(4-(Trifluoromethyl)Pyridin-3-Yl)Methanamine Dihydrochloride
CAS No.	1380300-26-4
Molecular Formula	C7H8Cl2F3N2
Molecular Weight	263.05 g/mol
Synonyms	3-(Aminomethyl)-4-(trifluoromethyl)pyridine dihydrochloride; 1-[4-(Trifluoromethyl)pyridin-3-yl]methanamine dihydrochloride; 4-(Trifluoromethyl)-3-pyridinemethanamine dihydrochloride; (4-Trifluoromethyl-3-pyridyl)methylamine dihydrochloride; 3-Pyridinemethanamine, 4-(trifluoromethyl)-, dihydrochloride; 4-(Trifluoromethyl)pyridin-3-ylmethylamine hydrochloride (1:2)
EINECS	Contact for details

Quality Control

Our (4-(Trifluoromethyl)Pyridin-3-Yl)Methanamine Dihydrochloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation from moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.