Description

1,3-Diethynyl-4,6-Difluorobenzene is a specialized fluorinated aromatic building block featuring two terminal alkyne groups. This compound is valued for its role as a key monomer in the synthesis of advanced polymeric materials, particularly through cross-coupling and cycloaddition reactions. It is primarily utilized by researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for developing novel compounds with tailored electronic and structural properties.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those requiring fluorinated aromatic scaffolds.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and pesticides where the difluorobenzene core enhances biological activity and stability.
• Advanced Polymer Chemistry: Acts as a monomer for creating specialty polymers, including poly(arylene ethynylene)s (PAEs) and other conjugated polymers for electronic and optoelectronic applications.
• Material Science Research: Employed in the development of organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs) due to its rigid, linear ethynyl linkages and fluorine substitution.
• Cross-Coupling Reactions: A versatile substrate for Sonogashira, Glaser, and other palladium-catalyzed coupling reactions to construct complex molecular architectures.
• Ligand and Catalyst Development: Useful for synthesizing novel chelating ligands and organometallic catalysts in academic and industrial research settings.

Basic Information

Item	Detail
Product Name	1,3-Diethynyl-4,6-Difluorobenzene
CAS No.	1379822-11-3
Molecular Formula	C10H4F2
Molecular Weight	162.14 g/mol
Synonyms	4,6-Difluoro-1,3-diethynylbenzene; 1,3-Bis(ethynyl)-4,6-difluorobenzene; 4,6-Difluororesorcinol diethynyl ether; 4,6-Difluoro-m-diethynylbenzene; 1,3-Diethynyl-4,6-difluorobenzene; Difluorinated DEB; DFDEB
EINECS	Contact for details

Quality Control

Our 1,3-Diethynyl-4,6-Difluorobenzene is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, GC for residual solvents, and NMR/IR for structural confirmation, to ensure it meets rigorous specifications for research and industrial use. Certificates of Analysis (COA) documenting all critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Due to its sensitivity to light and oxidation, prolonged exposure to air and light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.