Description

9-Propoxymethyl-10-Hydroxy Camptothecin is a semi-synthetic derivative of the potent topoisomerase I inhibitor, camptothecin. This compound is engineered to enhance solubility and stability while retaining significant anti-tumor activity, making it a valuable intermediate in advanced pharmaceutical research and development. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and synthesis of novel chemotherapeutic agents targeting various cancers.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of next-generation camptothecin-based anticancer drugs.
• Oncology Research: Used as a reference standard and active compound in in vitro and in vivo studies to evaluate efficacy against tumor cell lines.
• Drug Discovery Programs: Serves as a core scaffold for medicinal chemistry efforts aimed at improving pharmacokinetic profiles and reducing toxicity.
• Biochemical Research: Employed in studies investigating the mechanism of action of topoisomerase I inhibitors and DNA damage response pathways.
• Preclinical Development: Utilized in formulation studies for developing injectable or oral dosage forms of experimental anticancer therapies.

Basic Information

Product Name	9-Propoxymethyl-10-Hydroxy Camptothecin
CAS No.	1379512-11-4
Molecular Formula	C24H22N2O6
Molecular Weight	434.44 g/mol
Synonyms	10-Hydroxy-9-propoxymethylcamptothecin; 9-Propoxymethyl-10-hydroxy-20(S)-camptothecin; Camptothecin, 10-hydroxy-9-(propoxymethyl)-; (S)-10-Hydroxy-9-(propoxymethyl)camptothecin; 9-PM-10-HC; 9-Propoxymethyl-10-HC; 9-PM-10-Hydroxy CPT
EINECS	Contact for details

Quality Control

Our 9-Propoxymethyl-10-Hydroxy Camptothecin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm the (S)-configuration, and identification via IR and NMR spectroscopy. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with research-grade specifications. Our quality commitment supports critical pharmaceutical R&D where consistency and data integrity are paramount.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. The product is light-sensitive and easily oxidized; allow it to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	Yellow to light yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% (S-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.