Description

1-Difluoromethyl-1H-Pyrazole-3-Carbonitrile is a high-value, fluorinated pyrazole derivative serving as a critical synthetic intermediate in advanced organic chemistry. Its core value lies in the strategic incorporation of a difluoromethyl group and a nitrile functionality, which are pivotal for modulating the physicochemical and biological properties of target molecules. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries engaged in the discovery and development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting enzyme inhibition.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the difluoromethyl group can enhance metabolic stability and bioavailability.
• Chemical Biology Probe Development: Serves as a versatile scaffold for creating molecular probes to study biological pathways and protein functions.
• Material Science Research: Investigated as a precursor for specialty polymers and advanced materials with unique electronic or surface properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client projects.

Basic Information

Item	Detail
Product Name	1-Difluoromethyl-1H-Pyrazole-3-Carbonitrile
CAS No.	1379276-84-2
Molecular Formula	C5H3F2N3
Molecular Weight	143.10 g/mol
Synonyms	1-(Difluoromethyl)-1H-pyrazole-3-carbonitrile; 3-Cyano-1-(difluoromethyl)-1H-pyrazole; 1H-Pyrazole-3-carbonitrile, 1-(difluoromethyl)-; Difluoromethylpyrazolecarbonitrile
EINECS	Contact for details

Quality Control

Every batch of 1-Difluoromethyl-1H-Pyrazole-3-Carbonitrile is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the identity, purity, and consistency of our product meet the exacting standards required for research and development. A Certificate of Analysis (COA) detailing specifications such as assay (HPLC), identity (IR, NMR), and impurity profile is available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong alkalis and incompatible materials. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.