Description

5-Fluoropyridine-2-Carboxylic Acid tert-Butyl Ester is a high-value fluorinated pyridine derivative, serving as a critical protected intermediate in advanced organic synthesis. Its primary commercial value lies in enabling the efficient construction of complex molecules, particularly in the pharmaceutical sector where the introduction of fluorine atoms is a key strategy for modulating bioactivity and metabolic stability. This compound is essential for research chemists and process development scientists working on active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated drug candidates, including kinase inhibitors and central nervous system (CNS) active compounds.
• Agrochemical Research: Used in developing novel pesticides and herbicides where the fluoropyridine moiety contributes to efficacy and environmental profile.
• Chemical Synthesis: Serves as a versatile precursor for coupling reactions (e.g., Suzuki, Sonogashira) and further functionalization due to the reactive carboxylic acid ester and fluorinated aromatic ring.
• Material Science: Potential monomer or intermediate for creating specialty polymers and liquid crystals with unique electronic properties.
• Contract Research & Development (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up services for the life sciences industry.

Basic Information

Product Name	5-Fluoropyridine-2-Carboxylic Acid tert-Butyl Ester
CAS No.	1379037-04-3
Molecular Formula	C10H12FNO2
Molecular Weight	197.21 g/mol
Synonyms	tert-Butyl 5-fluoropicolinate; 5-Fluoro-2-pyridinecarboxylic acid 1,1-dimethylethyl ester; 5-Fluoropyridine-2-carboxylic acid 1,1-dimethylethyl ester; 2-Pyridinecarboxylic acid, 5-fluoro-, 1,1-dimethylethyl ester; 5-Fluoro-2-picolinic acid tert-butyl ester; tert-Butyl 5-fluoro-2-pyridinecarboxylate; 5-Fluoropicolinic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our 5-Fluoropyridine-2-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliable batch-to-batch consistency for your research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Recommended storage temperature is between 2°C and 8°C for long-term stability. Keep away from strong bases and incompatible materials. The container must be kept tightly closed in a dry and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.