Description

(4R)-4-[(S)-Hydroxyphenylmethyl]-2,2-Dimethyl-3-Oxazolidinecarboxylic-13C6 Acid tert-Butyl Ester is a high-purity, isotopically labeled chiral building block essential for advanced pharmaceutical research and development. Its core value lies in enabling precise metabolic and pharmacokinetic studies through the incorporation of a stable carbon-13 (13C6) isotope label. This compound is critically needed by research scientists and process chemists in the pharmaceutical, biotechnology, and contract research organization (CRO) sectors for the development and analysis of novel active pharmaceutical ingredients (APIs).

Application

• Isotope-Labeled Reference Standard: Serves as a critical internal standard for quantitative bioanalytical methods, including LC-MS/MS, ensuring accurate measurement of drug concentrations in biological matrices.
• Metabolic Pathway Tracing: Used in drug metabolism and pharmacokinetics (DMPK) studies to elucidate metabolic pathways and identify metabolites in preclinical and clinical research.
• Chiral Intermediate Synthesis: Acts as a key chiral synthon in the asymmetric synthesis of complex pharmaceutical molecules, leveraging its defined (4R) and (S) stereochemistry.
• Process Chemistry & Scale-Up: Employed in the development and optimization of synthetic routes for labeled APIs, supporting scale-up from milligram to kilogram quantities.
• Regulatory Submissions: Provides essential data for regulatory filings (e.g., with the FDA, EMA) requiring detailed understanding of a drug's absorption, distribution, metabolism, and excretion (ADME) profile.
• Proteomics & Biomarker Research: Can be utilized in specialized proteomic studies and as a tracer in biomarker discovery and validation workflows.

Basic Information

Product Name	(4R)-4-[(S)-Hydroxyphenylmethyl]-2,2-Dimethyl-3-Oxazolidinecarboxylic-13C6 Acid tert-Butyl Ester
CAS No.	1377320-83-6
Molecular Formula	C1713C6H25NO4
Molecular Weight	~311.4 g/mol (for 13C6 labeled form)
Synonyms	(4R,5S)-4-(Hydroxy(phenyl)methyl)-2,2-dimethyl-5-oxo-1,3-oxazolidine-3-carboxylic-13C6 acid tert-butyl ester; tert-Butyl (4R,5S)-4-(hydroxy(phenyl)methyl)-2,2-dimethyl-5-oxo-1,3-oxazolidine-3-carboxylate-13C6; (4R-cis)-4-(α-Hydroxybenzyl)-2,2-dimethyl-5-oxo-3-oxazolidinecarboxylic-13C6 Acid 1,1-Dimethylethyl Ester; 13C6-Labeled (4R,5S)-4-Benzyl-2,2-dimethyl-5-oxo-3-oxazolidinecarboxylic acid tert-butyl ester; Chiral Oxazolidinone-13C6 tert-Butyl Ester; Stable Isotope Labeled Evans Auxiliary Derivative
EINECS	Contact for details

Quality Control

Our (4R)-4-[(S)-Hydroxyphenylmethyl]-2,2-Dimethyl-3-Oxazolidinecarboxylic-13C6 Acid tert-Butyl Ester is manufactured under strict quality systems to ensure batch-to-batch consistency and high isotopic purity. Each lot undergoes comprehensive analysis including HPLC for chemical purity, NMR and MS for structural and isotopic confirmation, and chiral analysis to verify enantiomeric excess. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (13C6)	≥ 99 atom % 13C
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.