Description

trans-(3-Fluoro-Piperidin-4-Yl)Methyl-Carbamic Acid tert-Butyl Ester is a high-purity, fluorinated piperidine derivative serving as a critical building block in modern organic synthesis. Its value lies in providing a protected amine and a versatile fluorinated heterocyclic scaffold, enabling the efficient construction of complex molecules with tailored properties. This advanced intermediate is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the discovery and process development of new active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and metabolic disorder research.
• Medicinal Chemistry Building Block: Used in structure-activity relationship (SAR) studies and lead optimization campaigns to introduce fluorinated piperidine motifs.
• Agrochemical Research: Serves as a precursor in the synthesis of new generation herbicides, fungicides, and insecticides requiring fluorinated heterocycles.
• Chemical Biology Probe Synthesis: Utilized to create labeled or tagged compounds for studying biological pathways and target engagement.
• Process Chemistry & Scale-up: Employed in route scouting and optimization for the commercial-scale production of fluorinated target molecules.
• Custom Synthesis & Contract Manufacturing: A starting material for specialized chemical service providers offering bespoke synthesis to client specifications.

Basic Information

Product Name	trans-(3-Fluoro-Piperidin-4-Yl)Methyl-Carbamic Acid tert-Butyl Ester
CAS No.	1376609-36-7
Molecular Formula	C12H23FN2O2
Molecular Weight	246.32 g/mol
Synonyms	tert-Butyl N-[[(3R,4S)-3-fluoropiperidin-4-yl]methyl]carbamate; (3R,4S)-4-[[(tert-Butoxycarbonyl)amino]methyl]-3-fluoropiperidine; trans-4-((tert-Butoxycarbonylamino)methyl)-3-fluoropiperidine; BOC-3-Fluoro-4-piperidinemethylamine; 1,1-Dimethylethyl N-[[(3R,4S)-3-fluoro-4-piperidinyl]methyl]carbamate; trans-N-Boc-3-fluoro-4-piperidinemethylamine; (trans)-4-(Boc-aminomethyl)-3-fluoropiperidine
EINECS	Contact for details

Quality Control

Our trans-(3-Fluoro-Piperidin-4-Yl)Methyl-Carbamic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specified parameters. Our quality commitment supports applications requiring high standards, including cGMP development and non-GMP research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep the container tightly sealed in a desiccated environment when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Assay	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.