Description

3-(Difluoromethyl)Pyrrolidine CAS NO 1376435-67-4 is a versatile fluorinated heterocyclic building block, a pyrrolidine derivative featuring a difluoromethyl substituent. This compound is valued for its ability to modulate the physicochemical and metabolic properties of target molecules, making it a critical intermediate in advanced synthetic chemistry. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the discovery and development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and metabolic disease targets.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the difluoromethyl group can enhance bioavailability and stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Incorporated into specialty polymers and advanced materials to impart unique fluorinated characteristics.
• Chemical Biology Probes: Utilized in the design of molecular probes and inhibitors for studying enzyme function and biological pathways.
• Fluorine Chemistry Research: An important compound for academic and industrial research focused on introducing fluorine motifs into complex molecules.

Basic Information

Product Name	3-(Difluoromethyl)Pyrrolidine
CAS No.	1376435-67-4
Molecular Formula	C5H9F2N
Molecular Weight	121.13 g/mol
Synonyms	3-(Difluoromethyl)pyrrolidine; Pyrrolidine, 3-(difluoromethyl)-; 3-Difluoromethylpyrrolidine; 1-Azabicyclo[3.1.0]hexane, 3-(difluoromethyl)-; 1376435-67-4
EINECS	Contact for details

Quality Control

Our 3-(Difluoromethyl)Pyrrolidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment to guarantee traceability and batch-to-batch consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong alkalis and incompatible materials. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.