Description

2-(1-Phenyl-Cyclopropylamino)-Pyrimidine-5-Carboxylic Acid Hydroxyamide is a high-purity, advanced pharmaceutical intermediate with a distinct heterocyclic structure. This compound is valued for its role as a critical building block in the research and development of novel therapeutic agents, particularly in oncology and epigenetics. It is primarily sought by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in innovative drug discovery programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of targeted cancer therapies and histone deacetylase (HDAC) inhibitors.
• Biochemical Research: Used as a reference standard and active probe in enzymatic and cellular assays for epigenetic research.
• Preclinical Development: Serves as a critical material for pharmacokinetic, pharmacodynamic, and toxicology studies during drug candidate optimization.
• Academic Research: Employed in university and institutional labs for studying structure-activity relationships (SAR) in medicinal chemistry projects.
• Custom Synthesis: A starting material for the contract manufacturing of specialized, non-commercial APIs for clinical trials.

Basic Information

Item	Detail
Product Name	2-(1-Phenyl-Cyclopropylamino)-Pyrimidine-5-Carboxylic Acid Hydroxyamide
CAS No.	1375465-91-0
Molecular Formula	C14H14N4O2
Molecular Weight	270.29 g/mol
Synonyms	2-[(1-Phenylcyclopropyl)amino]pyrimidine-5-carbohydroxamic acid; 2-(1-Phenylcyclopropylamino)pyrimidine-5-carboxylic acid hydroxyamide; 2-(1-Phenylcyclopropylamino)pyrimidine-5-carbohydroxamic acid; Phenylcyclopropylaminopyrimidine hydroxamic acid; HDAC Inhibitor Intermediate; CAS 1375465-91-0; 2-(1-Phenyl-cyclopropylamino)-pyrimidine-5-carboxylic acid hydroxyamide
EINECS	Contact for details

Quality Control

Every batch of 2-(1-Phenyl-Cyclopropylamino)-Pyrimidine-5-Carboxylic Acid Hydroxyamide is manufactured under strict quality management systems. We provide comprehensive analytical documentation, including HPLC chromatograms and NMR spectra, to verify identity and purity. A Certificate of Analysis (COA) detailing batch-specific results for purity, related substances, and residual solvents is supplied with each shipment to ensure traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.