Description

Methyl 6-(Difluoromethoxy)Nicotinate is a high-purity, specialized organic intermediate of significant importance in modern synthetic chemistry. Its core value lies in its unique difluoromethoxy-substituted pyridine structure, which is critical for modulating the biological activity and physicochemical properties of advanced target molecules. This compound is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders, metabolic diseases, and anti-inflammatory applications.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, where the difluoromethoxy group can enhance lipophilicity and metabolic stability.
• Material Science Precursor: Serves as a starting material for creating specialized ligands, catalysts, and functionalized polymers with tailored electronic properties.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client R&D programs.

Basic Information

Product Name	Methyl 6-(Difluoromethoxy)Nicotinate
CAS No.	1375098-06-8
Molecular Formula	C8H7F2NO3
Molecular Weight	203.14 g/mol
Synonyms	Methyl 6-(difluoromethoxy)pyridine-3-carboxylate; 3-Pyridinecarboxylic acid, 6-(difluoromethoxy)-, methyl ester; 6-(Difluoromethoxy)nicotinic acid methyl ester; Methyl 6-(difluoromethoxy)nicotinate; Methyl 6-O-difluoromethyl nicotinate
EINECS	Contact for details

Quality Control

Our Methyl 6-(Difluoromethoxy)Nicotinate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets the high-purity standards required for pharmaceutical and advanced chemical synthesis. We provide comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, ensuring reliable supply and batch-to-batch consistency for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.