Description

5-Chloropyridin-2-Ylmagnesium Bromide is a highly reactive organometallic reagent, specifically a Grignard reagent, essential for constructing complex molecular architectures. Its core value lies in enabling efficient carbon-carbon bond formation, a critical step in the synthesis of active pharmaceutical ingredients (APIs) and advanced agrochemicals. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for introducing the versatile 5-chloropyridin-2-yl moiety into target molecules.

Application

• Pharmaceutical Intermediate Synthesis: A key building block for creating novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) active compound research.
• Agrochemical Manufacturing: Used in the production of advanced herbicides, fungicides, and insecticides that require the chloropyridine scaffold for bioactivity.
• Material Science Research: Employed in the synthesis of functionalized ligands for catalysis and novel organic electronic materials.
• Cross-Coupling Reactions: Serves as a nucleophile in Kumada, Negishi, and other transition-metal-catalyzed cross-coupling reactions to form biaryl and heteroaryl structures.
• Nucleophilic Addition: Reacts with carbonyl compounds (aldehydes, ketones, esters) to produce secondary and tertiary alcohols with the chloropyridyl group.
• Custom Chemical Synthesis: A critical reagent for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.

Basic Information

Product Name	5-Chloropyridin-2-Ylmagnesium Bromide
CAS No.	1374995-84-2
Molecular Formula	C5H3ClMgNBr
Molecular Weight	216.74 g/mol
Synonyms	2-Chloro-5-pyridylmagnesium bromide; (5-Chloro-2-pyridinyl)magnesium bromide; 5-Chloro-2-pyridylmagnesium bromide; Magnesium, bromo(5-chloro-2-pyridinyl)-; 5-Chloro-2-pyridinemagnesium bromide; Grignard reagent 5-chloro-2-pyridylmagnesium bromide
EINECS	Contact for details

Quality Control

Every batch of 5-Chloropyridin-2-Ylmagnesium Bromide is manufactured and handled under strict inert atmosphere conditions to ensure reactivity and purity. Our quality assurance includes rigorous in-process controls and final testing. Certificates of Analysis (COA) detailing concentration (typically supplied as a solution in THF or diethyl ether), titration assay, and by-product levels are provided with each shipment to ensure compliance with your synthetic protocols.

Storage

Preserve in a tightly closed container, protected from light. This material is highly volatile, hygroscopic (moisture-sensitive), and easily oxidized (store under inert atmosphere). For optimal stability and safety, store the sealed reagent bottle under a dry, inert gas (argon or nitrogen) atmosphere at 2-8°C. Do not expose to air or moisture. Use only in a certified fume hood with appropriate personal protective equipment.

Specification

Item	Specification
Appearance	Clear to slightly colored solution
Concentration	0.5 M in THF (or as specified)
Assay (Titration)	≥ 95%
Identification (IR)	Conforms to structure
Water Content (KF)	≤ 100 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.