Description

Naldemedine CAS NO 1374774-70-5 is a selective peripherally-acting opioid receptor antagonist. This compound is of significant commercial and therapeutic importance for its targeted mechanism of action, which minimizes central nervous system side effects. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of treatments for opioid-induced constipation (OIC).

Application

• Active Pharmaceutical Ingredient (API) for the formulation of oral medications targeting opioid-induced constipation.
• Pharmaceutical Research & Development for studying peripheral opioid receptor pharmacology and novel therapeutic pathways.
• Reference Standard in analytical laboratories for quality control and method validation of drug products.
• Preclinical Studies to investigate the efficacy and safety profile of peripherally-acting antagonists.
• Contract Manufacturing for the production of generic or branded pharmaceutical formulations.
• Academic Research in neurogastroenterology and the gut-brain axis.

Basic Information

Product Name	Naldemedine
CAS No.	1374774-70-5
Molecular Formula	C32H34N4O6
Molecular Weight	570.64 g/mol
Synonyms	S-297995; Naldemedine Tosylate; (3S)-3-({[(1R)-1-{[(3R,4R)-4-(3-Hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]methyl}-2-methylpropyl]amino}methyl)-5-methyl-6-oxo-5,6-dihydro-1,3-oxazolo[3,4-a]pyrazin-8-ium; 1,3-Oxazolo[3,4-a]pyrazin-8-ium, 5,6-dihydro-5-methyl-6-oxo-3-[[[[1-(3-hydroxyphenyl)-3,4-dimethyl-4-piperidinyl]methyl](2-methylpropyl)amino]methyl]-, (3S)-; Symproic (Brand Name)
EINECS	Contact for details

Quality Control

Our Naldemedine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time conforms to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.